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Osteoarthritis (OA) is chronic degenerative musculoskeletal diseases, with higher prevalence in women. Knee is the common destruction of cartilage and bone changes a subchondral sclerosis and osteophyte. Patient present pain and disability and consequently impaired quality of life. Procedure: 30 participants were recruited based on inclusion and exclusion criteria. An informed consent was taken from the subjects. Low Level LASER therapy was administered in experimental group and Ultrasound therapy was administered to conventional group for a period of 5 times a week for 2 weeks. Pre on Day 1 and post on Day 10th assessment were taken by using Range of Motion (ROM) and Numerical Pain Rating Scale (NPRS). There was significant decrease in NPRS in patients which is suggestive of quality of life. Also, Knee ROM was found to be significantly increases amongst these participants. The outcome of NPRS and knee ROM was statistically analysed. It was found to be effective with significant P value<0.000. Conclusion: Ultrasound therapy is an effective treatment and can be used for treatment of patients with OA knee.