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Carcinoma Breast has become the most common malignancy noted in the Indian female population. The most comprehensive form of treatment associated with the least incidence of Recurrence as well as Diseasefree survival is considered to be Modified Radical Mastectomy with Systemic Chemotherapy along with Adjuvant radiotherapy when indicated. Collection of Serous fluid in the subcutaneous dead space, or seroma is the most Common Complication occurring post-operatively. For almost thirty years, Various Fibrin sealants, such as fibrin glue (FG) and fibrin spray, have been utilized in surgical procedures as tissue glue to bind subcutaneous tissue, as a supplement to hemostasis. and as a hemostatic and sealing agent