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Epithelial cancers of the aero digestive tract account for one third of all cancer deaths each year. Oral cancer is a significant health problem. Oral cancer is a major cause of morbidity and mortality in several developing countries comprising. Squamous cell carcinoma is the most common oral cancer accounting for 90-95% of all oral malignancies. Oral squamous cell carcinoma (OSCC) is the sixth most common malignancy and is a major cause of cancer morbidity and mortality worldwide. Globally about 500,000 new oral and pharyngeal cancers are diagnosed annually, and three quarters of these are from the developing world. According to WHO, about 90% of oral cancers in South East Asia is attributable to tobacco use.