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Neural tube defects (NTDs) are the group of specific birth defects (SBDs) is an opening of the cranium and spine from early development in the human [1]. Basically in the third week of the pregnancy called as gastrulating period in cells on the dorsal side of the embryo begins into their change shape and form the cranial neural tube (CNT) in the human brain [2]. The usual cranial neural tube (UCNT) does not close NTD [2]. Their neuronal cells develop at that time completely close UCNT [3]. The Specific types of NTD is including with the spina bifida (SB). The cranial, spine, anencephaly in the little to no brain, encephalocele affects in the babies skull, and iniencephaly results in the severe neck problems near to head [4].NTDs are one of the rarest to rare birth defects and affecting over 350,000 births in the worldwide including with Asian Indian countries annually