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T he main goal of periodontal tissue engineering is to regenerate the supporting tissues of the tooth. Tooth loss can be the result of trauma or periodontal conditions, including gingivitis, periodontitis, or age-related tissue decay. Periodontal tissue engineering strategies target two distinct goals, including the formation of new alveolar bone and connective tissue (cementum and periodontal ligament). If left untreated, periodontal disease invariably leads to the loss of the tooth, and it has been estimated that about 10% of the global population is affected by severe periodontitis [1]. Regenerative periodontal therapies aim, ideally, at healing all the damaged periodontal tissues and represent a significant clinical and societal challenge for the current ageing population.[2]. Replacing teeth with titanium dental implants is now a common procedure with a success rate of around 98%; however, it is still subject to some termination. Tooth replacement by using titanium dental implants is presently a routine procedure with a success rate of around 98%; however, it still suffers from some terminations. In this respect, it cannot be overlooked that the positive outcome of a titanium screw insertion basically depends on the amount and quality of the patient’s alveolar bone which can support the implant in the extraction site [3]; Therefore, developing appropriate strategies for hard tissue regeneration is of utmost importance in dental surgery. In the recent decades, the treatment of soft tissue defects has also gained increasing attention in order to prevent advanced forms of periodontal injuries related to mucogingival anomalies and better satisfy the aesthetic demands of patients [4].